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1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.

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Do not use a double dose to make up for the dose that you missed.

Do not reuse vials, needles or syringes. If needed, expel some product to obtain desired dose.

After removal from refrigerator, do not store product above 25 degrees C. Cover exposed needle with Pen cover. Do not hold the Pen cover with your hands while inserting the needle. The dose may be avomex increased once the enzyme concentrations have normalized. Variations in dosage exist among different interferon beta-1a products; these products are not equivalent.

The effects of interferon inssrt during labor and delivery are unknown. Things you must do: If the goal dose is 44 mcg, in weeks 1 to 2 administer 8.

It is not known whether these events were related to the effects of multiple sclerosis alone, interferon beta-1a therapy, or a combination of both.

Biogen Australia Pty Ltd. Interferon beta-1a-induced hematologic toxicity is dose related. Tell your doctor if you have or have had:.

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Overall, the HCV-HIV International Panel recommends the management of hepatotoxicity should be based on the knowledge of the mechanisms involved for each drug. Attach the needle by pressing it onto the syringe and turning it clockwise until it locks in place. Taking other medicines Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.


Your email has been sent. They occur with long-term treatment. However, a small number of nursing mothers receiving interferon beta-1a reported no adverse effects in their partially breast-fed infants, and the amount of interferon beta-1a excreted into breast milk appeared to be insignificant.

Glatiramer is a potential alternative to interferon beta-1a in the treatment of multiple sclerosis; the high molecular weight of the drug would suggest significant transfer to breast milk would be unlikely but no specific information regarding its use in breast-feeding is available.

Do not use the injection if the liquid is colored, cloudy, or has lumps or particles.

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Swelling of the face, lips, mouth or throat which may cause difficulty in swallowing or breathing. Do not expose to high temperatures. Severe liver injury, including some cases of hepatic failure requiring liver transplantation, has been reported rarely in patients taking. Refer to the Patient Medication Guide for detailed instructions for preparing and giving a dose.

If a dose is missed, administer it as soon as possible. Bictegravir; Emtricitabine; Tenofovir Alafenamide: Talk about this with your doctor or pharmacist if you want more information. Additionally, interferon beta-1a should not be used in patients with hamster protein hypersensitivity.

No adequate or well-controlled pregnancy studies have been done. You may need urgent medical attention. Release the skin and inject subcutaneously. It is important that a qualified health care professional supervises your first injection. Use of interferons during pregnancy should be avoided due to the risk of spontaneous abortion. The potential of additive effects from multiple drugs or other hepatotoxic agents has not been determined; however, caution is recommended if interferon beta-1a is given concurrently with any hepatotoxic agents.


Reduce the risk of relapse. To help further reduce these symptoms, your doctor may advise you to take a medication to reduce pain and inflammation before your injection and for up to one day afterwards.

This may have a favorable effect on remyelination. Sodium phosphate monobasic and dibasic. For storage information, see specific product avonez within the How Supplied section.

Reconstitution and Administration of Avonex lyophilized powder: Interferon beta-1a should be used with caution in patients with depression. Biologic response marker levels e. Major An increased risk and severity of peripheral neuropathy has been reported with telbivudine alone or in combination with pegylated interferon alfa-2a and other interferons. Administration of Inserrt pre-filled autoinjector: What it looks like Each Powder for Injection blister tray contains:. Discontinuation of interferon therapy is recommended.

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If it has expired or is damaged inssrt looks differently than it should, return it to your pharmacist for disposal. The manufacturer of Avonex offers free training on intramuscular injection administration for patients and their health care partners.

Cases have been reported several weeks to years after treatment initiation. If your doctor tells you to stop using AVONEX or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.

The cause of MS is not yet known.